Advancements in psychiatric care have ushered in a new age of mental health care, anchored by two groundbreaking treatments: Ketamine Therapy and Transcranial Magnetic Stimulation (TMS). These new developments create more treatment avenues for people living with treatment-resistant depression, but because of their relative novelty, it is challenging for some patients to determine which intervention is best for them. While there is no one-size-fits-all answer to the ketamine vs TMS debate, you may find that one treatment suits your needs better than the other depending on your medical history, symptoms, and lifestyle. This article covers the mechanisms of action, efficacy, and potential side effects to consider as you pursue one (or both) of these interventions.